SH2D4B

Across TCGA pan-cancer cohorts, SH2D4B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SH2D4B data layer compared with 5 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SH2D4B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SH2D4B expression acts as an unfavorable survival marker, although some lineages such as CESC and UVM show a favorable association.

CESC, UVM, and ACC are the cancer types where SH2D4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.853	0.655	<.001	104	view →
UVM	OS	Tertile	All	0.817	0.338	<.001	87	view →
ACC	OS	Tertile	II,III,IV	0.389	0.858	<.001	68	view →
KICH	DFS	Tertile	All	0.763	1.000	.005	51	view →
UCEC	DFS	Tertile	IV	0.765	0.281	.002	36	view →
LUSC	DFS	Quartile	III,IV	0.351	1.000	.011	30	view →
LGG	OS	Quartile	All	0.337	0.507	.001	28	view →
THCA	OS	Tertile	II,III,IV	0.954	0.991	.009	24	view →
SCLC	OS	Tertile	IV	0.201	0.829	.010	20	view →
SKCM	OS	Quartile	III,IV	0.545	0.327	.016	11	view →
TGCT	DFS	Median	All	0.927	0.736	.006	10	view →
ESCA	OS	Quartile	All	0.627	0.347	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SH2D4B–CESC (DFS)

Open the CESC breakdown →