SH2D4B

Across TCGA patient cohorts, SH2D4B mutation is significantly associated with the RNA expression of many other genes, with 2,672 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D4B-associated genes across cancer lineages are VN1R88P, DPRXP7, and PIGW. Each is linked with SH2D4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D4B-to-partner and partner-to-SH2D4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R88P grouped by SH2D4B-low versus SH2D4B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4B→partner) and Y-score (partner→SH2D4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VN1R88P →	+0.809	+5.324	<.001	.003	3	2
BRCA	DPRXP7 →	+0.091	+6.133	<.001	.001	3	2
UCEC	PIGW →	+0.514	+2.439	.002	.001	3	2
SKCM	FTH1P9 →	+0.027	+4.528	<.001	.003	3	2
LUAD	RNA5SP29 →	+0.759	+3.676	.002	.005	3	2
UCEC	MYO19 →	+0.441	+2.459	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,672 associations by consensus.

VN1R88P by SH2D4B expression — BRCA

Explore this box plot interactively →