SH2D4B

Across TCGA patient cohorts, SH2D4B mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D4B-associated genes across cancer lineages are ATM, Bax, and Di-Ras3. Each is linked with SH2D4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D4B-to-partner and partner-to-SH2D4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SH2D4B-low versus SH2D4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4B→partner) and Y-score (partner→SH2D4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.653	-3.794	<.001	<.001	3	2
UCEC	Bax →	+0.201	+1.765	.025	.014	3	2
UCEC	Di-Ras3 →	-0.164	-3.906	.003	<.001	3	2
UCEC	14-3-3_beta →	-0.089	-3.295	.017	.009	3	1
UCEC	EGFR_pY1068 →	-0.231	-2.169	.014	.003	3	1
UCEC	A-Raf_pS299 →	-0.117	-2.459	.009	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by SH2D4B expression — UCEC

Explore this box plot interactively →