SH2D4B

Across TCGA cell cohorts, SH2D4B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,667 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH2D4B-associated GO terms across cancer lineages are Protein folding, Regulation of postsynaptic membrane potential, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with SH2D4B in more than 8 cancer types. Because this analysis shows association rather than direction, both SH2D4B-to-partner and partner-to-SH2D4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein folding grouped by SH2D4B-low versus SH2D4B-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4B→partner) and Y-score (partner→SH2D4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Protein folding →	+0.032	+0.035	.006	.009	2	9
OVARY	Regulation of postsynaptic membrane potential →	-0.092	-0.086	<.001	.003	3	7
LARGE_INTESTINE	Negative regulation of mRNA splicing, via spliceosome →	+0.083	+0.047	.003	<.001	3	6
LARGE_INTESTINE	Negative regulation of mRNA processing →	+0.083	+0.034	<.001	.004	3	6
OVARY	Import across plasma membrane →	-0.055	-0.080	<.001	<.001	3	6
LUNG_NSCLC_LUSC	Negative regulation of chromosome organization →	+0.082	+0.105	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,667 associations by consensus.

Protein folding by SH2D4B expression — LUNG_NSCLC_LUAD

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