SH2D4B

Across TCGA cell cohorts, SH2D4B mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SH2D4B-associated genes across cancer lineages are SLC22A2, IL4, and ETV3L. Each is linked with SH2D4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D4B-to-partner and partner-to-SH2D4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A2 grouped by SH2D4B-low versus SH2D4B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4B→partner) and Y-score (partner→SH2D4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC22A2 →	+0.208	+3.551	<.001	.009	3	2
BLOOD_Myeloma	IL4 →	+0.157	+4.285	<.001	.003	3	1
BLOOD_Myeloma	ETV3L →	+0.012	+4.285	<.001	.003	3	1
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
OVARY	RESP18 →	+0.038	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

SLC22A2 by SH2D4B expression — BLOOD_Leukemia

Explore this box plot interactively →