SH2D3A

Across TCGA patient cohorts, SH2D3A RNA expression is significantly associated with the protein abundance of many other proteins, with 7,436 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SH2D3A-associated proteins across cancer lineages are SH2D3A_S180, SH2D3A_S201, and SH2D3A_S147. Each is linked with SH2D3A in more than 8 cancer types. Because this analysis shows association rather than direction, both SH2D3A-to-partner and partner-to-SH2D3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2D3A versus SH2D3A_S180 in OV, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3A→partner) and Y-score (partner→SH2D3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SH2D3A_S180 →	+1.259	+1.192	<.001	<.001	3	9
OV	SH2D3A_S201 →	+1.059	+0.642	<.001	.003	3	8
OV	SH2D3A_S147 →	+0.587	+0.951	<.001	<.001	3	7
OV	TRIP10 →	+0.540	+1.205	<.001	<.001	3	6
GBM	STXBP2 →	+0.459	+0.250	<.001	.002	3	5
OV	SH2D3A_S218 →	+1.251	+1.101	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,436 associations by consensus.

SH2D3A vs SH2D3A_S180 — OV

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