SH2D3A

Across TCGA patient cohorts, SH2D3A protein abundance is significantly associated with the RNA expression of many other genes, with 6,067 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH2D3A-associated genes across cancer lineages are SDC4, PTK6, and TRIP10. Each is linked with SH2D3A in more than 4 cancer types. Because this analysis shows association rather than direction, both SH2D3A-to-partner and partner-to-SH2D3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2D3A versus SDC4 in OV, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3A→partner) and Y-score (partner→SH2D3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SDC4 →	+1.260	+4.429	<.001	<.001	3	5
HNSC	PTK6 →	+1.250	+0.488	<.001	<.001	3	4
HNSC	TRIP10 →	+0.571	+0.315	.002	.009	3	4
UCEC	XDH →	+1.325	+0.250	<.001	.003	3	4
HNSC	ALS2CL →	+1.032	+0.506	<.001	<.001	3	4
UCEC	ANXA2 →	+0.960	+0.407	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,067 associations by consensus.

SH2D3A vs SDC4 — OV

Explore this scatter interactively →