SH2D3A

Across TCGA patient cohorts, SH2D3A protein abundance is significantly associated with the protein abundance of many other proteins, with 15,264 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SH2D3A-associated proteins across cancer lineages are SH2D3A_S180, SH2D3A_S218, and SH2D3A_S147. Each is linked with SH2D3A in more than 6 cancer types. Because this analysis shows association rather than direction, both SH2D3A-to-partner and partner-to-SH2D3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2D3A versus SH2D3A_S180 in BRCA, with a Pearson correlation of 0.66.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3A→partner) and Y-score (partner→SH2D3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH2D3A_S180 →	+0.989	+0.606	<.001	<.001	3	6
HNSC	SH2D3A_S218 →	+0.836	+0.528	<.001	<.001	3	6
LSCC	SH2D3A_S147 →	+0.520	+0.533	<.001	<.001	3	5
OV	SH2D3A_S201 →	+1.922	+3.962	.005	.009	1	7
HNSC	MARK2 →	+0.218	+0.476	<.001	<.001	3	5
LUAD	BCAR1 →	+0.325	+0.380	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,264 associations by consensus.

SH2D3A vs SH2D3A_S180 — BRCA

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