SH2D3A

Across TCGA patient cohorts, SH2D3A mutation is significantly associated with the RNA expression of many other genes, with 3,101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D3A-associated genes across cancer lineages are RPL12P39, CENPU, and SPC25. Each is linked with SH2D3A in more than 2 cancer types. Because this analysis shows association rather than direction, both SH2D3A-to-partner and partner-to-SH2D3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P39 grouped by SH2D3A-low versus SH2D3A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3A→partner) and Y-score (partner→SH2D3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RPL12P39 →	+0.157	+4.971	<.001	.002	3	3
UCEC	CENPU →	+0.707	+2.233	<.001	<.001	3	3
UCEC	SPC25 →	+0.518	+2.330	.009	.003	3	3
UCEC	CHAF1A →	+0.731	+2.606	<.001	<.001	3	3
UCEC	MASTL →	+0.499	+2.201	.003	<.001	3	3
UCEC	BARD1 →	+0.562	+3.711	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,101 associations by consensus.

RPL12P39 by SH2D3A expression — BLCA

Explore this box plot interactively →