SH2D3A

Across TCGA patient cohorts, SH2D3A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D3A-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and 14-3-3_beta. Each is linked with SH2D3A in more than 3 cancer types. Because this analysis shows association rather than direction, both SH2D3A-to-partner and partner-to-SH2D3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SH2D3A-low versus SH2D3A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3A→partner) and Y-score (partner→SH2D3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.427	+2.824	<.001	.034	3	4
UCEC	C-Raf →	+0.185	+1.807	<.001	.025	3	2
UCEC	14-3-3_beta →	-0.101	-1.973	.007	.029	3	1
UCEC	EGFR_pY1068 →	-0.259	-1.765	.005	.014	3	1
UCEC	A-Raf_pS299 →	-0.166	-2.115	<.001	.017	3	1
UCEC	ERK2 →	+0.192	+1.765	.007	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by SH2D3A expression — COAD

Explore this box plot interactively →