SH2D3A

Across TCGA cell cohorts, SH2D3A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,450 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SH2D3A-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Protein localization to cell-cell junction, and Cytotoxic T cell degranulation. Each is linked with SH2D3A in more than 14 cancer types. Because this analysis shows association rather than direction, both SH2D3A-to-partner and partner-to-SH2D3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by SH2D3A-low versus SH2D3A-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3A→partner) and Y-score (partner→SH2D3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.233	+1.720	<.001	.003	3	15
URINARY_TRACT	Protein localization to cell-cell junction →	+0.197	+3.682	<.001	<.001	3	13
STOMACH	Cytotoxic T cell degranulation →	+0.345	+3.357	<.001	<.001	3	13
SOFT_TISSUE	Bundle of His cell to Purkinje myocyte communication →	+0.777	+1.041	.002	.006	3	13
SOFT_TISSUE	Bundle of His cell-Purkinje myocyte adhesion involved in cell communication →	+0.856	+1.027	<.001	.001	3	13
LUNG_NSCLC_LUSC	Regulation of inner ear receptor cell differentiation →	+1.332	+2.123	.004	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,450 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by SH2D3A expression — PANCREAS

Explore this box plot interactively →