SH2D3A

Across TCGA cell cohorts, SH2D3A mutation is significantly associated with the mutation status of many other genes, with 5,272 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH2D3A-associated genes across cancer lineages are SMC1B, AGAP2, and GPC2. Each is linked with SH2D3A in more than 3 cancer types. Because this analysis shows association rather than direction, both SH2D3A-to-partner and partner-to-SH2D3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMC1B grouped by SH2D3A-low versus SH2D3A-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D3A→partner) and Y-score (partner→SH2D3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMC1B →	+4.857	+4.297	.009	.009	1	4
BLOOD_Lymphoma	AGAP2 →	+3.510	+4.108	.003	.003	1	4
BLOOD_Lymphoma	GPC2 →	+4.247	+4.554	.001	.001	1	4
BREAST	GALNT6 →	+4.442	+5.095	.001	.001	1	4
BLOOD_Leukemia	ATP10D →	+3.753	+5.347	<.001	<.001	1	4
SKIN	PCDH19 →	+3.655	+4.906	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,272 associations by consensus.

SMC1B by SH2D3A expression — BREAST

Explore this box plot interactively →