SH2D2A

Across TCGA patient cohorts, SH2D2A protein abundance is significantly associated with the RNA expression of many other genes, with 7,757 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH2D2A-associated genes across cancer lineages are TIFAB, SLC7A7, and TRAV13-2. Each is linked with SH2D2A in more than 4 cancer types. Because this analysis shows association rather than direction, both SH2D2A-to-partner and partner-to-SH2D2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2D2A versus TIFAB in UCEC, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D2A→partner) and Y-score (partner→SH2D2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIFAB →	+0.707	+1.165	.003	.007	3	5
HNSC	SLC7A7 →	+1.111	+0.504	<.001	<.001	3	5
UCEC	TRAV13-2 →	+0.926	+0.903	<.001	.006	3	4
HNSC	TRGV6 →	+1.143	+0.490	.004	.004	2	5
BRCA	IL2RB →	+1.424	+1.174	<.001	<.001	3	4
BRCA	SLA2 →	+1.213	+1.208	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,757 associations by consensus.

SH2D2A vs TIFAB — UCEC

Explore this scatter interactively →