SH2D2A

Across TCGA patient cohorts, SH2D2A mutation is significantly associated with the RNA expression of many other genes, with 822 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D2A-associated genes across cancer lineages are TTTY2B, MIR8082, and NPLP1. Each is linked with SH2D2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D2A-to-partner and partner-to-SH2D2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY2B grouped by SH2D2A-low versus SH2D2A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D2A→partner) and Y-score (partner→SH2D2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TTTY2B →	+0.009	+7.954	<.001	.008	3	2
SKCM	MIR8082 →	+0.364	+3.490	<.001	.008	3	2
UCEC	NPLP1 →	+0.205	+1.943	<.001	.007	3	2
UCEC	RNU6-120P →	+0.254	+3.008	<.001	.007	3	2
SKCM	MTND4P33 →	+0.032	+4.993	<.001	.002	3	2
COAD	RNU6-784P →	+0.403	+4.516	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 822 associations by consensus.

TTTY2B by SH2D2A expression — HNSC

Explore this box plot interactively →