SH2D2A

Across TCGA patient cohorts, SH2D2A mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D2A-associated genes across cancer lineages are Notch1, PCNA, and Lck. Each is linked with SH2D2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D2A-to-partner and partner-to-SH2D2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SH2D2A-low versus SH2D2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D2A→partner) and Y-score (partner→SH2D2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.208	+3.009	.007	.019	3	1
UCEC	PCNA →	+0.355	+3.000	.002	.036	2	1
UCEC	Lck →	+0.279	+3.169	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Notch1 by SH2D2A expression — UCEC

Explore this box plot interactively →