SH2D2A

Across TCGA cell cohorts, SH2D2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,425 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH2D2A-associated GO terms across cancer lineages are Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, Positive regulation of fibrinolysis, and Positive regulation of telomerase RNA localization to Cajal body. Each is linked with SH2D2A in more than 9 cancer types. Because this analysis shows association rather than direction, both SH2D2A-to-partner and partner-to-SH2D2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator grouped by SH2D2A-low versus SH2D2A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D2A→partner) and Y-score (partner→SH2D2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.119	+0.788	<.001	.005	2	9
OESOPHAGUS	Positive regulation of fibrinolysis →	+1.613	+1.935	<.001	.002	1	10
BLOOD_Leukemia	Positive regulation of telomerase RNA localization to Cajal body →	+0.050	+1.397	.006	<.001	3	7
LUNG_SCLC	Purine-containing compound biosynthetic process →	+0.074	+1.755	<.001	<.001	3	7
STOMACH	Body fluid secretion →	+0.210	+1.981	<.001	<.001	3	7
BONE	Lactation →	+0.167	+1.944	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,425 associations by consensus.

Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator by SH2D2A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →