SH2D2A

Across TCGA cell cohorts, SH2D2A mutation is significantly associated with the drug of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH2D2A-associated genes across cancer lineages are AZD8931, Ibrutinib, and SB216763. Each is linked with SH2D2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D2A-to-partner and partner-to-SH2D2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD8931 grouped by SH2D2A-low versus SH2D2A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D2A→partner) and Y-score (partner→SH2D2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AZD8931 →	+0.456	+2.761	.008	.041	3	1
BLOOD_Leukemia	Ibrutinib →	+0.548	+3.005	.015	.021	3	1
BLOOD_Leukemia	SB216763 →	+0.327	+2.879	.038	.027	2	1
BLOOD_Leukemia	KU-60019 →	+0.383	+2.919	.021	.025	2	1
BLOOD_Leukemia	Acetalax →	+0.217	+2.681	.040	.048	2	1
BLOOD_Leukemia	VX-702 →	+0.435	+2.881	.001	.026	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

AZD8931 by SH2D2A expression — BLOOD_Leukemia

Explore this box plot interactively →