SH2B2

Across TCGA patient cohorts, SH2B2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,065 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SH2B2-associated proteins across cancer lineages are CDYL_S216, HMGB2, and TPX2. Each is linked with SH2B2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SH2B2-to-partner and partner-to-SH2B2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2B2 versus CDYL_S216 in BRCA, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B2→partner) and Y-score (partner→SH2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDYL_S216 →	+0.674	+0.664	.003	.005	3	4
PDAC	HMGB2 →	+0.367	+0.463	<.001	<.001	3	4
UCEC	TPX2 →	+0.746	+0.689	<.001	.005	3	4
UCEC	CRYL1 →	-0.621	-0.770	<.001	<.001	3	4
BRCA	HSPA14 →	+0.344	+0.732	.002	.001	3	4
LUAD	MCM2_S139 →	+0.754	+0.480	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,065 associations by consensus.

SH2B2 vs CDYL_S216 — BRCA

Explore this scatter interactively →