SH2B2

Across TCGA patient cohorts, SH2B2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,081 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH2B2-associated genes across cancer lineages are RMND5A, FLVCR1, and ZNF543. Each is linked with SH2B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH2B2-to-partner and partner-to-SH2B2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2B2 versus RMND5A in LSCC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B2→partner) and Y-score (partner→SH2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RMND5A →	-0.659	-0.432	<.001	<.001	3	3
UCEC	FLVCR1 →	-0.622	-0.470	<.001	<.001	3	3
UCEC	ZNF543 →	-0.643	-0.562	.002	.004	3	3
PDAC	NCF1C →	+0.819	+0.602	.009	<.001	3	3
LUAD	PLS3-AS1 →	-0.534	-0.361	.004	.003	3	3
LSCC	ZNF263 →	-0.423	-0.539	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,081 associations by consensus.

SH2B2 vs RMND5A — LSCC

Explore this scatter interactively →