SH2B2

Across TCGA patient cohorts, SH2B2 mutation is significantly associated with the RNA expression of many other genes, with 1,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2B2-associated genes across cancer lineages are RNU6-1118P, RNU6-1213P, and RNU6-1150P. Each is linked with SH2B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH2B2-to-partner and partner-to-SH2B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1118P grouped by SH2B2-low versus SH2B2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B2→partner) and Y-score (partner→SH2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1118P →	+0.140	+4.302	<.001	.007	3	3
UCEC	RNU6-1213P →	+0.225	+3.654	<.001	.001	3	3
LUSC	RNU6-1150P →	+0.592	+5.151	<.001	.007	3	3
BLCA	MIR30A →	+0.557	+7.640	<.001	.009	3	2
COAD	TRAJ34 →	+0.731	+3.830	.004	.002	3	2
COAD	LINC00160 →	+0.176	+3.408	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,029 associations by consensus.

RNU6-1118P by SH2B2 expression — SKCM

Explore this box plot interactively →