SH2B2

Across TCGA patient cohorts, SH2B2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2B2-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eEF2. Each is linked with SH2B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2B2-to-partner and partner-to-SH2B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SH2B2-low versus SH2B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B2→partner) and Y-score (partner→SH2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.837	-3.446	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.740	+2.341	.005	.019	3	2
UCEC	eEF2 →	+0.485	+3.169	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.333	-2.700	.003	.006	3	1
UCEC	eIF4E →	+0.218	+2.700	.021	.006	3	1
UCEC	A-Raf_pS299 →	-0.168	-3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by SH2B2 expression — UCEC

Explore this box plot interactively →