SH2B2

Across TCGA cell cohorts, SH2B2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,005 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SH2B2-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Ribonucleoside triphosphate biosynthetic process, and Nucleoside triphosphate biosynthetic process. Each is linked with SH2B2 in more than 13 cancer types. Because this analysis shows association rather than direction, both SH2B2-to-partner and partner-to-SH2B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by SH2B2-low versus SH2B2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B2→partner) and Y-score (partner→SH2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Pre-mRNA catabolic process →	+0.165	+0.800	<.001	<.001	3	14
LUNG_SCLC	Ribonucleoside triphosphate biosynthetic process →	+0.115	+0.972	<.001	.002	3	11
PANCREAS	Nucleoside triphosphate biosynthetic process →	+0.079	+0.541	<.001	.008	3	10
LUNG_SCLC	Purine nucleoside triphosphate biosynthetic process →	+0.113	+0.998	<.001	.002	3	10
LUNG_SCLC	Purine ribonucleoside triphosphate biosynthetic process →	+0.113	+0.998	<.001	.002	3	10
KIDNEY	Regulation of isotype switching to IgG isotypes →	+0.105	+1.068	<.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,005 associations by consensus.

Pre-mRNA catabolic process by SH2B2 expression — SKIN

Explore this box plot interactively →