SH2B1

Across TCGA pan-cancer cohorts, SH2B1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SH2B1 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SH2B1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SH2B1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, STAD, and UCEC are the cancer types where SH2B1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.146	0.768	<.001	24	view →
STAD	OS	Median	II,III,IV	0.183	0.677	.004	24	view →
UCEC	DFS	Median	II,III,IV	1.000	0.437	.016	20	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SH2B1–HNSC (OS)

Open the HNSC breakdown →