SH2B1

Across TCGA pan-cancer cohorts, SH2B1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SH2B1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SH2B1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SH2B1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where SH2B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.930	.003	19	view →
PDAC	DFS	Tertile	III,IV	0.371	0.923	.006	18	view →
CCRCC	OS	Tertile	All	0.928	0.751	.013	16	view →
GBM	OS	Median	All	0.633	0.436	.025	7	view →
LSCC	DFS	Tertile	III,IV	0.411	0.777	.031	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SH2B1–HNSC (OS)

Open the HNSC breakdown →