SH2B1

Across TCGA patient cohorts, SH2B1 mutation is significantly associated with the RNA expression of many other genes, with 2,590 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2B1-associated genes across cancer lineages are MS4A13, ADAMTS17, and CLCN4. Each is linked with SH2B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SH2B1-to-partner and partner-to-SH2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A13 grouped by SH2B1-low versus SH2B1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B1→partner) and Y-score (partner→SH2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MS4A13 →	+0.206	+3.082	<.001	.002	3	3
SKCM	ADAMTS17 →	-0.686	-2.836	.001	.002	3	2
SKCM	CLCN4 →	-0.862	-2.900	.007	.001	2	3
UCEC	IGSF22 →	-0.375	-3.545	<.001	.002	3	2
UCEC	FAHD1 →	+0.443	+3.354	.001	.005	3	2
UCEC	NOP10 →	+0.553	+3.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,590 associations by consensus.

MS4A13 by SH2B1 expression — LUAD

Explore this box plot interactively →