SH2B1

Across TCGA cell cohorts, SH2B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,735 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH2B1-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Viral transcription, and Positive regulation of intracellular estrogen receptor signaling pathway. Each is linked with SH2B1 in more than 17 cancer types. Because this analysis shows association rather than direction, both SH2B1-to-partner and partner-to-SH2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by SH2B1-low versus SH2B1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B1→partner) and Y-score (partner→SH2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.188	+1.118	<.001	<.001	3	18
BONE	Viral transcription →	+0.125	+1.239	<.001	<.001	3	17
OESOPHAGUS	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.202	+0.906	.001	.008	3	17
BONE	Pre-mRNA catabolic process →	+0.215	+1.062	<.001	<.001	3	16
BONE	Regulation of alternative mRNA splicing, via spliceosome →	+0.092	+1.097	<.001	<.001	3	16
STOMACH	Negative regulation of myoblast fusion →	+0.116	+0.670	.001	.005	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,735 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by SH2B1 expression — OESOPHAGUS

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