SH2B1

Across TCGA cell cohorts, SH2B1 mutation is significantly associated with the RNA expression of many other genes, with 868 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH2B1-associated genes across cancer lineages are OR10T2, TLE7, and LRP5L. Each is linked with SH2B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2B1-to-partner and partner-to-SH2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by SH2B1-low versus SH2B1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2B1→partner) and Y-score (partner→SH2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10T2 →	+0.584	+4.276	.005	.007	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
LARGE_INTESTINE	LRP5L →	+0.842	+3.502	.001	.001	3	1
LARGE_INTESTINE	EIF3L →	+0.496	+3.502	.004	.001	3	1
LARGE_INTESTINE	MIOX →	+0.360	+3.410	<.001	.002	3	1
LARGE_INTESTINE	RPL3 →	+0.582	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 868 associations by consensus.

OR10T2 by SH2B1 expression — BLOOD_Leukemia

Explore this box plot interactively →