SGSM3

Across TCGA cell cohorts, SGSM3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SGSM3-associated genes across cancer lineages are MYL10, OR1L3, and UCN3. Each is linked with SGSM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGSM3-to-partner and partner-to-SGSM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL10 grouped by SGSM3-low versus SGSM3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSM3→partner) and Y-score (partner→SGSM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MYL10 →	+0.461	+4.017	.003	.007	3	2
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	UCN3 →	+0.031	+4.977	<.001	.007	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TMEM235 →	+0.006	+2.882	.002	.005	3	1
CNS	KLK9 →	+0.683	+6.357	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MYL10 by SGSM3 expression — OESOPHAGUS

Explore this box plot interactively →