SGSM2

Across TCGA patient cohorts, SGSM2 mutation is significantly associated with the RNA expression of many other genes, with 2,919 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGSM2-associated genes across cancer lineages are DCLRE1B, RNU6-275P, and CLSPN. Each is linked with SGSM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SGSM2-to-partner and partner-to-SGSM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCLRE1B grouped by SGSM2-low versus SGSM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSM2→partner) and Y-score (partner→SGSM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCLRE1B →	+0.355	+1.950	.004	.002	3	4
CESC	RNU6-275P →	+0.215	+4.569	<.001	.005	3	3
COAD	CLSPN →	+0.748	+3.459	<.001	.005	3	3
UCEC	ARHGAP11A →	+0.469	+2.087	.005	.005	3	3
UCEC	IGHD1-26 →	+0.395	+2.292	<.001	<.001	3	3
UCEC	XPNPEP1 →	+0.305	+2.010	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,919 associations by consensus.

DCLRE1B by SGSM2 expression — UCEC

Explore this box plot interactively →