SGSM2

Across TCGA pan-cancer cohorts, SGSM2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SGSM2 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SGSM2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SGSM2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

UVM, ACC, and HNSC are the cancer types where SGSM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.385	0.859	<.001	130	view →
ACC	DFS	Median	All	0.219	0.648	<.001	91	view →
HNSC	OS	Quartile	III,IV	0.511	0.201	.001	81	view →
KIRC	DFS	Quartile	II,III,IV	0.340	0.636	.001	61	view →
PAAD	OS	Tertile	All	0.547	0.262	<.001	60	view →
KICH	OS	Median	All	0.674	1.000	.002	37	view →
MESO	DFS	Tertile	III,IV	0.214	0.437	.004	32	view →
KIRP	DFS	Tertile	All	0.953	0.825	.001	32	view →
COAD	DFS	Median	III,IV	0.322	0.681	.003	30	view →
ESCA	OS	Quartile	III,IV	0.652	0.371	.012	25	view →
BRCA	OS	Tertile	III,IV	0.971	0.841	.001	23	view →
LGG	OS	Median	All	0.930	0.850	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SGSM2–UVM (OS)

Open the UVM breakdown →