SGSM2

Across TCGA cell cohorts, SGSM2 mutation is significantly associated with the RNA expression of many other genes, with 830 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SGSM2-associated genes across cancer lineages are KDSR, NUP43, and FNBP1L. Each is linked with SGSM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGSM2-to-partner and partner-to-SGSM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDSR grouped by SGSM2-low versus SGSM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSM2→partner) and Y-score (partner→SGSM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KDSR →	+0.866	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	NUP43 →	+0.559	+2.628	<.001	.002	3	2
LARGE_INTESTINE	FNBP1L →	+0.554	+3.169	.006	.009	3	2
LARGE_INTESTINE	RABGGTB →	+0.765	+3.459	<.001	.001	3	2
LARGE_INTESTINE	CHAC2 →	+0.705	+2.628	.002	.002	3	2
LARGE_INTESTINE	CHCHD4 →	+0.570	+3.389	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 830 associations by consensus.

KDSR by SGSM2 expression — LARGE_INTESTINE

Explore this box plot interactively →