SGSH

Across TCGA cell cohorts, SGSH mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SGSH-associated genes across cancer lineages are TBC1D3, GABRA6, and HABP2. Each is linked with SGSH in more than 1 cancer types. Because this analysis shows association rather than direction, both SGSH-to-partner and partner-to-SGSH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by SGSH-low versus SGSH-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSH→partner) and Y-score (partner→SGSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TBC1D3 →	+0.779	+3.276	<.001	.003	3	2
BLOOD_Leukemia	GABRA6 →	+0.293	+3.177	<.001	.004	3	1
BLOOD_Leukemia	HABP2 →	+0.385	+3.007	<.001	.007	3	1
BLOOD_Leukemia	AQP12B →	+0.202	+2.926	<.001	.009	3	1
BLOOD_Leukemia	ATP13A5 →	+0.082	+3.528	<.001	.008	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.097	+2.716	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TBC1D3 by SGSH expression — BLOOD_Lymphoma

Explore this box plot interactively →