SGK1

Across TCGA pan-cancer cohorts, SGK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SGK1 data layer compared with 21 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SGK1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SGK1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

GBM, LSCC, and HNSC are the cancer types where SGK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.251	0.590	.002	34	view →
LSCC	DFS	Tertile	All	0.814	0.571	.025	8	view →
HNSC	DFS	Median	All	0.800	0.419	.037	8	view →
UCEC	DFS	Median	II,III,IV	0.391	1.000	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SGK1–GBM (OS)

Open the GBM breakdown →