SGK1

Across TCGA pan-cancer cohorts, SGK1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SGK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SGK1 RNA is repressed in tumor relative to normal tissue. In most cancer types SGK1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where SGK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SGK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.420	<.001	11	view →
COAD	Male	IV	−3.118	<.001	11	view →
THCA	Male	III,IV	−2.157	<.001	9	view →
BLCA	All	All	−1.276	.007	7	view →
LUAD	Male	All	−1.167	<.001	7	view →
UCEC	All	II,III,IV	−1.920	<.001	6	view →
BRCA	All	III,IV	−1.509	<.001	6	view →
LIHC	Male	All	−0.979	<.001	3	view →
READ	All	All	−1.790	.009	2	view →
KIRP	Female	II,III,IV	−1.248	.018	2	view →
PRAD	All	All	−0.886	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SGK1–KICH

Open the KICH breakdown →