SGK1

Across TCGA patient cohorts, SGK1 mutation is significantly associated with the RNA expression of many other genes, with 4,195 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGK1-associated genes across cancer lineages are RNA5SP414, RNA5SP418, and INCENP. Each is linked with SGK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGK1-to-partner and partner-to-SGK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by SGK1-low versus SGK1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGK1→partner) and Y-score (partner→SGK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP414 →	+0.367	+4.295	<.001	.006	3	3
UCEC	RNA5SP418 →	+0.452	+1.430	<.001	.008	3	3
UCEC	INCENP →	+0.603	+1.680	<.001	<.001	3	2
UCEC	WAS →	+0.496	+1.432	.001	.005	3	2
UCEC	TATDN2 →	+0.224	+2.346	.007	<.001	3	2
UCEC	CCNB2 →	+0.667	+2.099	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,195 associations by consensus.

RNA5SP414 by SGK1 expression — LUSC

Explore this box plot interactively →