SGK1

Across TCGA cell cohorts, SGK1 mutation is significantly associated with the drug of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SGK1-associated genes across cancer lineages are PF-00299804, CP466722, and WYE-125132. Each is linked with SGK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGK1-to-partner and partner-to-SGK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PF-00299804 grouped by SGK1-low versus SGK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGK1→partner) and Y-score (partner→SGK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PF-00299804 →	+0.589	+2.652	.011	.045	3	2
LARGE_INTESTINE	CP466722 →	+0.451	+2.652	.022	.045	3	1
LARGE_INTESTINE	WYE-125132 →	+0.535	+2.652	.036	.045	3	1
LARGE_INTESTINE	CI-1033 →	+0.691	+2.652	.021	.045	3	1
LARGE_INTESTINE	Oxaliplatin →	+0.543	+2.649	.040	.046	2	1
LARGE_INTESTINE	AZD5991 →	+1.043	+2.649	.005	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PF-00299804 by SGK1 expression — LARGE_INTESTINE

Explore this box plot interactively →