SGIP1

Across TCGA pan-cancer cohorts, SGIP1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SGIP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SGIP1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SGIP1 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where SGIP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SGIP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.637	<.001	8	view →
LSCC	Male	III,IV	−0.853	<.001	7	view →
HNSC	All	All	−0.410	.015	6	view →
PDAC	All	All	+0.399	.004	4	view →
CCRCC	Female	All	+0.447	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SGIP1–LUAD

Open the LUAD breakdown →