SGIP1

Across TCGA pan-cancer cohorts, SGIP1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SGIP1 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SGIP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SGIP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

KIRP, UVM, and LUAD are the cancer types where SGIP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.711	0.940	<.001	78	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	51	view →
LUAD	OS	Median	II,III,IV	0.580	0.319	<.001	49	view →
SKCM	OS	Quartile	II,III,IV	0.423	0.215	.005	35	view →
HNSC	DFS	Median	III,IV	0.741	0.614	.015	18	view →
ACC	DFS	Tertile	All	0.534	0.941	.004	15	view →
COAD	OS	Quartile	II,III,IV	0.924	0.726	.012	13	view →
STAD	OS	Quartile	III,IV	0.231	0.723	.025	9	view →
MESO	OS	Median	II,III,IV	0.220	0.391	.033	6	view →
DLBC	DFS	Median	III,IV	1.000	0.525	.013	6	view →
TGCT	DFS	Quartile	All	0.585	0.776	.032	6	view →
LAML	DFS	Median	All	0.697	0.459	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SGIP1–KIRP (OS)

Open the KIRP breakdown →