SGIP1

Across TCGA patient cohorts, SGIP1 mutation is significantly associated with the RNA expression of many other genes, with 3,280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGIP1-associated genes across cancer lineages are MND1, LSM3, and ORC6. Each is linked with SGIP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SGIP1-to-partner and partner-to-SGIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MND1 grouped by SGIP1-low versus SGIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGIP1→partner) and Y-score (partner→SGIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MND1 →	+0.501	+1.675	.001	.001	3	4
UCEC	LSM3 →	+0.405	+1.402	<.001	.001	3	4
UCEC	ORC6 →	+0.457	+1.412	<.001	<.001	3	4
LUAD	KIF22 →	+0.611	+3.712	<.001	<.001	3	3
LUAD	PDRG1 →	+0.325	+1.871	.009	.005	3	3
LUAD	GEMIN2 →	+0.457	+2.746	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,280 associations by consensus.

MND1 by SGIP1 expression — UCEC

Explore this box plot interactively →