SGIP1

Across TCGA patient cohorts, SGIP1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGIP1-associated genes across cancer lineages are Cyclin-B1, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with SGIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGIP1-to-partner and partner-to-SGIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SGIP1-low versus SGIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGIP1→partner) and Y-score (partner→SGIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.535	+1.807	<.001	.003	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.363	-1.415	.003	.008	3	3
UCEC	PDCD4 →	-0.430	-1.584	<.001	.007	3	3
UCEC	Caspase-7-cleavedD198 →	+0.434	+1.171	.007	.031	3	3
SKCM	beta-Catenin →	-0.401	-3.000	.048	.034	3	2
UCEC	eIF4E →	+0.163	+1.917	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Cyclin-B1 by SGIP1 expression — UCEC

Explore this box plot interactively →