SGIP1

Across TCGA cell cohorts, SGIP1 mutation is significantly associated with the RNA expression of many other genes, with 317 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SGIP1-associated genes across cancer lineages are DEPDC5, LYZL2, and PRAMEF10. Each is linked with SGIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGIP1-to-partner and partner-to-SGIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEPDC5 grouped by SGIP1-low versus SGIP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGIP1→partner) and Y-score (partner→SGIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEPDC5 →	+0.523	+3.502	.006	.001	3	2
LUNG_SCLC	LYZL2 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	SULT1C3 →	+0.161	+3.523	.003	.008	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF25 →	+0.134	+3.523	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 317 associations by consensus.

DEPDC5 by SGIP1 expression — LARGE_INTESTINE

Explore this box plot interactively →