Across TCGA patient cohorts, SGCZ mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCZ-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and MEK1. Each is linked with SGCZ in more than 2 cancer types. Because this analysis shows association rather than direction, both SGCZ-to-partner and partner-to-SGCZ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCZ→partner) and Y-score (partner→SGCZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.512	+2.135	.012	.010	3	3
UCEC	Cyclin-B1 →	+0.694	+3.807	<.001	<.001	3	3
UCEC	MEK1 →	+0.407	+3.087	.001	<.001	3	2
UCEC	IGFBP2 →	-0.795	-2.700	<.001	.005	3	2
UCEC	PCNA →	+0.231	+2.700	.001	.005	3	2
UCEC	STAT3_pY705 →	-0.315	-1.405	<.001	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

SGCZ survival (RNA) · tumor vs normal (RNA) · all SGCZ data types