Across TCGA pan-cancer cohorts, SGCZ RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SGCZ data layer compared with 9 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SGCZ RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SGCZ expression acts as an unfavorable survival marker, although some lineages such as UVM and LGG show a favorable association.
KIRC, ACC, and STAD are the cancer types where SGCZ RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.