Across TCGA cell cohorts, SGCZ mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SGCZ-associated genes across cancer lineages are OR8D2, C10orf53, and DMRTC2. Each is linked with SGCZ in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCZ-to-partner and partner-to-SGCZ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCZ→partner) and Y-score (partner→SGCZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR8D2 →	+0.028	+3.700	<.001	.009	3	2
SOFT_TISSUE	C10orf53 →	+0.009	+4.369	<.001	.008	3	1
OESOPHAGUS	DMRTC2 →	+0.006	+4.906	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF12 →	+0.044	+3.562	.001	.002	3	1
LARGE_INTESTINE	BRDT →	+0.074	+3.333	.005	.009	3	1
LARGE_INTESTINE	CCDC54 →	+0.114	+3.447	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

SGCZ survival (RNA) · tumor vs normal (RNA) · all SGCZ data types