SGCE

Across TCGA pan-cancer cohorts, SGCE mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SGCE data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SGCE mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SGCE expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where SGCE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.452	0.870	<.001	43	view →
PDAC	DFS	Median	II,III,IV	0.644	0.896	.002	27	view →
HNSC	OS	Tertile	II,III,IV	0.947	0.762	.004	10	view →
UCEC	DFS	Median	All	0.936	1.000	.021	6	view →
CCRCC	OS	Median	III,IV	0.657	1.000	.012	3	view →
GBM	OS	Tertile	All	0.910	0.698	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SGCE–LSCC (DFS)

Open the LSCC breakdown →