SGCE

Across TCGA patient cohorts, SGCE mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCE-associated genes across cancer lineages are JNK_pT183_Y185, mTOR_pS2448, and STAT5a. Each is linked with SGCE in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCE-to-partner and partner-to-SGCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SGCE-low versus SGCE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCE→partner) and Y-score (partner→SGCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.158	-1.807	.012	.025	3	2
UCEC	mTOR_pS2448 →	-0.111	-1.765	.048	.014	3	2
UCEC	STAT5a →	+0.306	+1.765	.041	.014	3	2
UCEC	TFRC →	+0.612	+3.584	.002	.002	3	2
UCEC	A-Raf_pS299 →	-0.150	-3.700	<.001	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.113	-1.765	.015	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

JNK_pT183_Y185 by SGCE expression — UCEC

Explore this box plot interactively →