SGCE

Across TCGA cell cohorts, SGCE mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SGCE-associated genes across cancer lineages are TBC1D21, TSPY2, and FABP12. Each is linked with SGCE in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCE-to-partner and partner-to-SGCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by SGCE-low versus SGCE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCE→partner) and Y-score (partner→SGCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TSPY2 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	FABP12 →	+0.046	+3.632	<.001	.003	3	1
BLOOD_Leukemia	B3GAT1 →	+1.117	+3.643	<.001	.006	3	1
BLOOD_Leukemia	VSX2 →	+0.025	+3.258	<.001	.007	3	1
BLOOD_Leukemia	PRB2 →	+0.104	+3.169	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TBC1D21 by SGCE expression — LARGE_INTESTINE

Explore this box plot interactively →