SGCB

Across TCGA patient cohorts, SGCB mutation is significantly associated with the RNA expression of many other genes, with 2,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCB-associated genes across cancer lineages are PGBD4P2, RPL30P12, and YWHABP1. Each is linked with SGCB in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCB-to-partner and partner-to-SGCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGBD4P2 grouped by SGCB-low versus SGCB-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCB→partner) and Y-score (partner→SGCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	PGBD4P2 →	+0.096	+4.672	<.001	.004	3	2
UCEC	RPL30P12 →	+0.146	+2.047	<.001	.001	3	2
COAD	YWHABP1 →	+0.289	+3.870	<.001	.004	3	2
CESC	OR1E3 →	+0.052	+5.306	<.001	.006	3	2
UCEC	RIIAD1 →	-0.857	-2.692	.003	.006	3	1
UCEC	GAK →	+0.329	+1.789	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,435 associations by consensus.

PGBD4P2 by SGCB expression — READ

Explore this box plot interactively →