SGCB

Across TCGA pan-cancer cohorts, SGCB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SGCB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SGCB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SGCB is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KIRC, KICH, and BLCA are the cancer types where SGCB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SGCB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.114	<.001	12	view →
KICH	Male	II,III,IV	−1.935	<.001	9	view →
BLCA	All	All	−1.281	<.001	8	view →
LUSC	All	All	−0.556	<.001	8	view →
LUAD	Female	III,IV	−1.233	<.001	7	view →
UCEC	All	All	−0.888	<.001	6	view →
BRCA	All	III,IV	−0.884	<.001	6	view →
HNSC	All	III,IV	+0.627	.010	5	view →
COAD	Female	All	−0.690	.001	4	view →
CHOL	All	All	+1.556	<.001	3	view →
READ	Female	All	−1.710	.002	2	view →
PRAD	All	All	−0.959	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SGCB–KIRC

Open the KIRC breakdown →