SGCB

Across TCGA patient cohorts, SGCB mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCB-associated genes across cancer lineages are Notch1, TFRC, and ASNS. Each is linked with SGCB in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCB-to-partner and partner-to-SGCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SGCB-low versus SGCB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCB→partner) and Y-score (partner→SGCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.131	+1.884	.013	.030	3	2
UCEC	TFRC →	+0.587	+3.584	.003	.002	3	2
UCEC	ASNS →	+0.369	+2.115	.006	.017	3	2
UCEC	BRD4 →	+0.292	+3.321	.005	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.751	+2.135	<.001	.010	3	2
UCEC	c-Kit →	-0.181	-1.415	.038	.046	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Notch1 by SGCB expression — UCEC

Explore this box plot interactively →